Title :
Development of a fiber optic-based CARS exoscope for the in vivo study of spinal cord disorders
Author :
Murugkar, Sangeeta ; Smith, Brett ; Brideau, Craig ; Stys, Peter ; Anis, Hanan
Author_Institution :
Sch. of Inf. Technol. & Eng. (SITE), Univ. of Ottawa, Ottawa, ON, Canada
Abstract :
This paper describes our development of a fiber optic, MEMS-scanning based multimodal miniature microscope for in vivo nonlinear optical imaging of the spinal cord. The novel design of the exoscope will enable serial examinations of the status of the myelin sheath over time in the same animal by means of CARS microscopy. The basic design concept, major engineering challenges, solutions, and some preliminary results are presented.
Keywords :
bioMEMS; biomedical equipment; biomedical optical imaging; coherent antiStokes Raman scattering; fibre optic sensors; microsensors; neurophysiology; optical microscopes; MEMS-scanning; fiber optic-based CARS exoscope design; in vivo nonlinear optical imaging; multimodal miniature microscope; myelin sheath; spinal cord disorder; Microscopy; Mirrors; Optical fibers; Optical imaging; Spinal cord;
Conference_Titel :
Life Science Systems and Applications Workshop (LiSSA), 2011 IEEE/NIH
Conference_Location :
Bethesda, MD
Print_ISBN :
978-1-4577-0421-5
DOI :
10.1109/LISSA.2011.5754165
