Chimeric ferritin nanocages-based imaging probes

Author

Lin, Xin ; Xie, Jin ; Chen, Xiaoyuan

fYear

2011

fDate

7-8 April 2011

Firstpage

129

Lastpage

130

Abstract

Ferritin is a family of proteins found in different forms in most living organisms. Each ferritin is made up of 24 subunits, which self-assemble to form a cage-like nanostructure, with external and internal diameters of 12 and 8 nm, respectively. This unique architecture provides two interfaces—one outside and one inside—for possible functional loading. These interesting features make ferritin a powerful, capacious nanoplatform with potential in a wide spectrum of applications.

Keywords

biomedical materials; biomedical optical imaging; dyes; fluorescence spectroscopy; molecular biophysics; nanomedicine; nanostructured materials; proteins; radiation quenching; BHQ-3; Cy5.5 tagged peptide; MMP rich environment; PLGVR core peptide sequence; black hole quencher; cage like nanostructure; chemically modified ferritin nanocages; chimeric ferritin nanocage based imaging probes; compositional control; dye; ferritin nanocage disassembly; ferritin nanocage reassembly; ferritin proteins family; function hybridization; functional loading; genetically modified ferritin nanocages; metal cations; multifunctional ferritin nanostructures; multimodality imaging probes; nanomedicine; Imaging; Loading; Metals; Mice; Peptides; Probes; Proteins;

fLanguage

English

Publisher

ieee

Conference_Titel

Life Science Systems and Applications Workshop (LiSSA), 2011 IEEE/NIH

Conference_Location

Bethesda, MD

Print_ISBN

978-1-4577-0421-5

Type

conf

DOI

10.1109/LISSA.2011.5754175

Filename

5754175