A medical microsensor for blood glucose monitoring

Author

Chen, Oscal T C ; Wang, Sandy ; Lin, Chii-Wann ; Lu, Yao-Chon

Author_Institution

Dept. of Electr. Eng., Nat. Chung Cheng Univ., Chia-Yi, Taiwan

Volume

4

fYear

1997

fDate

9-12 Jun 1997

Firstpage

2761

Abstract

The fabrication and characterization of a microelectronic-based sensor for blood glucose are presented. This microsensor consists of a two-electrode electrochemical cell and a current-to-voltage amplifier. It is implemented by using the TSMC 0.6 u CMOS technology with the die size of 1.0 mm×1.0 mm. The enzymatic area of this two-electrode cell is 600 u×800 u that is enough to generate the dynamic range of the induced currents from 0 to 300 nA. According to the simulation results, a linear conversion of the current-to-voltage amplifier can be achieved with a rate of 12 mV per nano-ampere that can sense blood glucose concentration of 0.026 mM. The proposed microsensor can perform correct operations of amplification, calibration, and signal transformation from the chemical reactions. The prototype meter is also explored to provide rapid interpretation of blood glucose concentration at home or hospitals

Keywords

CMOS integrated circuits; biomedical electronics; biosensors; blood; electrochemical analysis; microsensors; patient monitoring; 0 to 300 nA; 0.6 micron; CMOS technology; blood glucose monitoring; calibration; chemical reaction; current-to-voltage amplifier; dynamic range; enzyme membrane; linear conversion; medical microsensor; signal transformation; two-electrode electrochemical cell; Biomedical monitoring; Blood; CMOS technology; Calibration; Chemicals; Dynamic range; Fabrication; Microsensors; Sensor phenomena and characterization; Sugar;

fLanguage

English

Publisher

ieee

Conference_Titel

Circuits and Systems, 1997. ISCAS '97., Proceedings of 1997 IEEE International Symposium on

Print_ISBN

0-7803-3583-X

Type

conf

DOI

10.1109/ISCAS.1997.612897

Filename

612897