DocumentCode :
3005430
Title :
Label-free detection of DNA hybridization with Au/SiO2/Si diodes and poly-Si TFTs
Author :
Estrela, Pedro ; Stewart, Andrew G. ; Migliorato, Piero ; Maeda, Hiroshi
Author_Institution :
Dept. of Eng., Cambridge Univ., UK
fYear :
2004
fDate :
13-15 Dec. 2004
Firstpage :
1009
Lastpage :
1012
Abstract :
Label-free electrical detection of DNA hybridization has been achieved by employing Au/SiO2/Si MOS diodes and poly-Si TFTs. The detection is based on the modulation of the gate voltage associated with the increased negative charge on the gate upon hybridization. The method can be applied to other bio-reactions that result in a modification of surface dipoles.
Keywords :
DNA; MOS integrated circuits; bioelectric phenomena; biosensors; chemical reactions; semiconductor diodes; Au-SiO2-Si; Au/SiO2/Si diode; DNA hybridization; MOS diode; bioreactions; electrical detection; gate voltage modulation; label-free detection; negative charge; poly-Si TFT; surface dipole modification; Artificial intelligence; Capacitance-voltage characteristics; DNA; Diodes; Electrodes; Gold; Impedance measurement; Measurement standards; Passivation; Probes;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Electron Devices Meeting, 2004. IEDM Technical Digest. IEEE International
Print_ISBN :
0-7803-8684-1
Type :
conf
DOI :
10.1109/IEDM.2004.1419359
Filename :
1419359
Link To Document :
https://search.ricest.ac.ir/dl/search/defaultta.aspx?DTC=49&DC=3005430
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