• DocumentCode
    3005430
  • Title

    Label-free detection of DNA hybridization with Au/SiO2/Si diodes and poly-Si TFTs

  • Author

    Estrela, Pedro ; Stewart, Andrew G. ; Migliorato, Piero ; Maeda, Hiroshi

  • Author_Institution
    Dept. of Eng., Cambridge Univ., UK
  • fYear
    2004
  • fDate
    13-15 Dec. 2004
  • Firstpage
    1009
  • Lastpage
    1012
  • Abstract
    Label-free electrical detection of DNA hybridization has been achieved by employing Au/SiO2/Si MOS diodes and poly-Si TFTs. The detection is based on the modulation of the gate voltage associated with the increased negative charge on the gate upon hybridization. The method can be applied to other bio-reactions that result in a modification of surface dipoles.
  • Keywords
    DNA; MOS integrated circuits; bioelectric phenomena; biosensors; chemical reactions; semiconductor diodes; Au-SiO2-Si; Au/SiO2/Si diode; DNA hybridization; MOS diode; bioreactions; electrical detection; gate voltage modulation; label-free detection; negative charge; poly-Si TFT; surface dipole modification; Artificial intelligence; Capacitance-voltage characteristics; DNA; Diodes; Electrodes; Gold; Impedance measurement; Measurement standards; Passivation; Probes;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Electron Devices Meeting, 2004. IEDM Technical Digest. IEEE International
  • Print_ISBN
    0-7803-8684-1
  • Type

    conf

  • DOI
    10.1109/IEDM.2004.1419359
  • Filename
    1419359
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=3005430