Multimodal Optical Tissue Imaging

This paper presents tissue imaging with a multimodal multiphoton microscopy (MPM) and optical coherence tomography (OCT) system. The multimodal system can acquire multiple contrasts including two-photon excited fluorescence, second harmonic generation, and scattering. The system can also acquire tissue level imaging with OCT and cellular level imaging with MPM. The MPM/OCT imaging is demonstrated on onion skin and cornea samples. The multimodal MPM/OCT provides a multi-contrast and multi-field-of-view imaging system which has potential applications in cancer detection and diagnosis.