Title :
A simplified probing controller for glucose feeding in Escherichia coli cultivations
Author :
Åkesson, Mats ; Hagander, Per
Author_Institution :
Dept. of Autom. Control, Lund Inst. of Technol., Sweden
Abstract :
A strategy for control of the glucose feed rate in cultivations of E. coli is discussed. By making probing pulses in the feed rate it is possible to detect and avoid a characteristic saturation linked to undesirable by-product formation. A simplification of a previous algorithm is presented and analyzed
Keywords :
biotechnology; chemical variables control; closed loop systems; feedback; process control; stability; E. coli; Escherichia coli cultivations; characteristic saturation; glucose feed rate; glucose feeding; probing pulses; simplified probing controller; Algorithm design and analysis; Automatic control; DNA; Feeds; Mass production; Microorganisms; Organisms; Probes; Proteins; Sugar;
Conference_Titel :
Decision and Control, 2000. Proceedings of the 39th IEEE Conference on
Conference_Location :
Sydney, NSW
Print_ISBN :
0-7803-6638-7
DOI :
10.1109/CDC.2001.914623
