Title :
A Synaptogenic Pacing Cell Line
Author :
Silva, Ricardo ; Barrett, Eric ; Kowal, Jamie ; Kim, Ji-Sung ; Allcock, Harry ; Gaumond, Roger
Author_Institution :
Dept. of Bioeng., Pennsylvania State Univ., University Park, PA
Abstract :
The SK-N-BE(2c) is an I-type neuroblastoma that develops a strong pacing electrical response over time. This response is likely the result of a developing interconnected network, such that the regular pacemaker-like firing of individual cells becomes synchronous over time forming a multi unit spikes signal (MUS). Immuno-fluorescence was used to show the presence of pre and postsynaptic markers, suggesting that MUS are the result of networking. Hence this cell line could prove as a useful model for synaptic dopaminergic pacing cell systems
Keywords :
bioelectric phenomena; cellular biophysics; fluorescence; neurophysiology; I-type neuroblastoma; SK-N-BE(2c); immuno-fluorescence; multi unit spikes signal; strong pacing electrical response; synaptic dopaminergic pacing cell systems; synaptogenic pacing cell line; synchronous regular pacemaker-like firing; Amino acids; Biomedical engineering; Chemistry; Electrodes; Immune system; Indium tin oxide; Neurotransmitters; Performance gain; Robustness; Time factors;
Conference_Titel :
Neural Engineering, 2005. Conference Proceedings. 2nd International IEEE EMBS Conference on
Conference_Location :
Arlington, VA
Print_ISBN :
0-7803-8710-4
DOI :
10.1109/CNE.2005.1419606
