An Analog VLSI Stimulation and Recording System for Extracelluar Interfacing

Author

Blum, Richard A. ; Ross, James D. ; Brown, Edgar A. ; DeWeerth, Stephen P.

Author_Institution

Lab. for Neuroeng., Georgia Inst. of Technol., Atlanta, GA

fYear

2005

fDate

16-19 March 2005

Firstpage

381

Lastpage

384

Abstract

This paper presents an analog VLSI system for extracellular interfacing to in vitro neural cultures on multielectrode arrays (MEAs). The design offers significant advantages: scalability to large numbers of electrodes, experimental flexibility in stimulation patterns, and suppression of stimulus artifacts. The paper includes experimental data demonstrating the performance of the recording system. Through the use of artifact suppression circuitry, the system reduces the duration of stimulus artifacts to < 2 ms. This reduction is effective for the stimulation electrode as well as neighboring electrodes

Keywords

VLSI; arrays; biomedical equipment; cellular biophysics; microelectrodes; neurophysiology; analog VLSI stimulation; artifact suppression circuitry; experimental flexibility; extracellular interfacing; in vitro neural cultures; multielectrode arrays; recording system; scalability; stimulation patterns; Circuits; Electrodes; Extracellular; In vitro; Laboratories; Neural engineering; Scalability; Spatial resolution; Very large scale integration; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering, 2005. Conference Proceedings. 2nd International IEEE EMBS Conference on

Conference_Location

Arlington, VA

Print_ISBN

0-7803-8710-4

Type

conf

DOI

10.1109/CNE.2005.1419638

Filename

1419638