Activation-Blood Flow Coupling During Direct Somatosensory Cortical Stimulation in Living Rat Brain

Author

Luo, Zhongchi ; Benveniste, Helene ; Yu, Mei ; Du, Congwu

Author_Institution

Medical Dept., Brookhaven Nat. Lab., Upton, NY

fYear

2005

fDate

16-19 March 2005

Firstpage

664

Lastpage

666

Abstract

Laser Doppler flowmetry was used to characterize the cortical activation-blood flow coupling due to direct stimulation in somatosensory cortex of rat brain in vivo. Both amplitude and duration of the flow response increased along with the increases in stimulation current. Flow response became to saturate in a high-grade stimulation with the current above 0.3 mA. The flow response also featured a fast activation due to the stimulus and a slow recovery, which may imply an indirect coupling between neural activity and recruitment of local blood delivery

Keywords

Doppler measurement; brain; flowmeters; haemodynamics; laser applications in medicine; somatosensory phenomena; cortical activation-blood flow coupling; direct somatosensory cortical stimulation; laser Doppler flowmetry; living rat brain; local blood delivery; neural activity; somatosensory cortex; Animals; Biomedical monitoring; Biomedical optical imaging; Blood flow; Electrical stimulation; In vivo; Optical scattering; Rats; Red blood cells; Stimulated emission;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering, 2005. Conference Proceedings. 2nd International IEEE EMBS Conference on

Conference_Location

Arlington, VA

Print_ISBN

0-7803-8710-4

Type

conf

DOI

10.1109/CNE.2005.1419712

Filename

1419712