DocumentCode
3014481
Title
Effects of nuisance parameters on the family-based linkage tests under general disease models
Author
Chen, Kuang-Chi
Author_Institution
Div. of Molecular & Genomic Medicine, Nat. Health Res. Institutes, Taipei, Taiwan
fYear
2004
fDate
10-12 May 2004
Firstpage
614
Lastpage
618
Abstract
Family-based linkage tests are methods for detection of the genetic basis of a disease. For the case-parent triad data, it is known that tests of linkage interfere with the association parameter under recessive disease models. The purpose of the paper is to discuss the effects of nuisance parameters on the family-based linkage tests under general models. It is shown that the linkage tests do not only interfere with the association parameter, but also with the gene substitution effect in general models.
Keywords
biology computing; diseases; genetics; case-parent triad data; family-based linkage tests; gene substitution effect; general disease models; genetic disease basis; nuisance parameters; recessive disease models; Bioinformatics; Couplings; Diseases; Frequency; Genetics; Genomics; Humans; Medical tests; Prostate cancer; Testing;
fLanguage
English
Publisher
ieee
Conference_Titel
Parallel Architectures, Algorithms and Networks, 2004. Proceedings. 7th International Symposium on
ISSN
1087-4089
Print_ISBN
0-7695-2135-5
Type
conf
DOI
10.1109/ISPAN.2004.1300546
Filename
1300546
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