Title :
Detection of weak nano-biosensor signals corrupted by shot noise
Author :
Wanzhi Qiu ; Thanh Cong Nguyen ; Skafidas, E.
Author_Institution :
Dept. of Electr. & Electron. Eng., Univ. of Melbourne, Parkville, VIC, Australia
Abstract :
Nano-scale biosensors have been identified as the next generation devices for biological and chemical sensing applications and fast sequencing of the human genome. However, detecting targeted molecules is proven to be a challenging task due to weak signal strengths and strong noises. It is therefore vital to understand the noise statistics and develop effective signal detection techniques in order to facilitate the development of reliable devices. In this paper, we build on molecular dynamics simulation results which reveal that the ionic current signals of DNA translocations through solid-state nanopores include both thermal and shot noise, and develop algorithms for effective detection of these signals. Theoretical and simulation results show that the locally most powerful detector has the potential to significantly outperform the classical matched filter.
Keywords :
DNA; biochemistry; bioelectric phenomena; biosensors; chemical sensors; matched filters; medical signal detection; molecular biophysics; molecular dynamics method; nanobiotechnology; nanosensors; shot noise; thermal noise; DNA translocations; biological sensing applications; chemical sensing applications; classical matched filter; effective signal detection techniques; fast human genome sequencing; ionic current signals; molecular dynamics simulation; nanoscale biosensors; next generation devices; noise statistics; reliable device development; shot noise; solid-state nanopores; strong noises; targeted molecule detection; thermal noise; weak nanobiosensor signal detection; weak signal strengths; Australia; DNA; Detectors; Nanobioscience; Noise; Numerical models; Thermal noise;
Conference_Titel :
Nanotechnology (IEEE-NANO), 2013 13th IEEE Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4799-0675-8
DOI :
10.1109/NANO.2013.6720842