Ultrasound activated paclitaxel delivery in mice using a combined therapy and imaging probe system

Author

Shi, William T. ; Böhmer, Marcel ; Celebi, Muzaffer ; Van Wamel, Annemieke ; Chin, Chien Ting ; Chlon, Ceciel ; Klibanov, Alexander L. ; Hall, Christopher S.

Author_Institution

Philips Res. North America, Scarborough, ME

fYear

2008

fDate

2-5 Nov. 2008

Firstpage

337

Lastpage

340

Abstract

Localized therapeutic effects of an experimental therapeutic agent on a mouse MC38 tumor model were evaluated using a combined ultrasound therapy and imaging probe system (TIPS). With ultrasound activated paclitaxel delivery, the tumor growth is substantially retarded for at least 3 days. The therapeutic effect of ultrasound is statistically significant (p=0.03) within one day after treatment but gradually decreases with time. Therefore, it is suggested that multiple treatments over a long period are required for cancer treatment. It is also demonstrated in this preclinical study that TIPS is an effective tool for imaging-guided, ultrasound-activated drug delivery.

Keywords

biomedical ultrasonics; cancer; drug delivery systems; tumours; ultrasonic imaging; TIPS system; cancer treatment; experimental therapeutic agent; imaging probe system; imaging-guided ultrasound-activated drug delivery; localized therapeutic effect; mouse MC38 tumor model; tumor growth retardation; ultrasound activated paclitaxel delivery; ultrasound therapeutic effect; Drug delivery; Laboratories; Medical treatment; Mice; Neoplasms; Permeability; Petroleum; Polymers; Probes; Ultrasonic imaging; drug delivery; microcapsule; mouse tumor model; paclitaxel; ultrasound contrast agent; ultrasound therapy;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 2008. IUS 2008. IEEE

Conference_Location

Beijing

Print_ISBN

978-1-4244-2428-3

Electronic_ISBN

978-1-4244-2480-1

Type

conf

DOI

10.1109/ULTSYM.2008.0083

Filename

4803354