Histotripsy for the treatment of BPH: evaluation in a chronic canine model

Author

Hall, Timothy L. ; Hempel, Chris R. ; Lake, Alison M. ; Kieran, Kathy ; Ives, Kim ; Fowlkes, J. Brian ; Cain, Charles A. ; Roberts, William W.

Author_Institution

Depts. of Urology, Univ. of Michigan, Ann Arbor, MI

fYear

2008

fDate

2-5 Nov. 2008

Firstpage

765

Lastpage

767

Abstract

Histotripsy was evaluated as a non-invasive BPH treatment. The prostates of 20 canine subjects were targeted with one of three histotripsy doses. Prostates were harvested immediately, 7 days, or 28 days after treatment and assessed for changes. Lower treatment doses were found to produced scattered cellular disruption and hemorrhage that was sometimes reversible. Higher doses perforated the urethra and produced cavities in the glandular prostate that healed to leave an enlarged urinary channel.

Keywords

biological effects of acoustic radiation; biological organs; biological tissues; diseases; medical disorders; ultrasonic therapy; BPH treatment; benign prostate hyperplasia; chronic canine model; enlarged urinary channel; glandular prostate tissue; hemorrhage; histotripsy treatment dose; scattered cellular disruption; ultrasound therapy; urethra perforation; Abdomen; Acoustic scattering; Bladder; Focusing; Hemorrhaging; Lakes; Medical treatment; Probes; Transducers; Ultrasonic imaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 2008. IUS 2008. IEEE

Conference_Location

Beijing

Print_ISBN

978-1-4244-2428-3

Electronic_ISBN

978-1-4244-2480-1

Type

conf

DOI

10.1109/ULTSYM.2008.0183

Filename

4803437