Title :
Contrast-enhanced high-frequency ultrasound imaging of liver metastases in preclinical models
Author :
Rui Chen ; Tomita, N. ; Baba, Taisuke ; Oosawa, F. ; Watanabe, Yoshihiro ; Horie, Shota ; Mori, Shiro ; Fukumoto, Manabu ; Kodama, Tetsuya
Author_Institution :
Dept. of Biomed. Eng., Tohoku Univ., Tohoku
Abstract :
Preclinical mouse models are essential to the study of liver metastasis, yet their utility has been limited by difficulty in tracking the progression of metastases through time. In this study, liver metastases were identified by in vivo bioluminescence system and a high-frequency ultrasound system with nanobubbles. Tumor grows and vessel densities were calculated. Liver metastases were observed on the second days after inoculation and confirmed by the HE staining. Vessels density in the liver metastasis group was increased compared to the control group. This study show that three-dimensional high-frequency ultrasound imaging combined with nanobubbles may be suited for early detection, quantitative assessment of metastatic progression in liver metastasis models.
Keywords :
bioacoustics; bioluminescence; biomedical ultrasonics; cancer; liver; patient diagnosis; tumours; HE staining; contrast-enhanced high-frequency ultrasound imaging; in vivo bioluminescence system; liver metastasis; nanobubbles; preclinical mouse model; tumor; vessel density; Acoustic imaging; Bioluminescence; Cancer; In vivo; Liver; Magnetic resonance imaging; Metastasis; Mice; Optical imaging; Ultrasonic imaging; high-frequency ultrasound; in vivo bioluminescence system; liver metastasis;
Conference_Titel :
Ultrasonics Symposium, 2008. IUS 2008. IEEE
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2428-3
Electronic_ISBN :
978-1-4244-2480-1
DOI :
10.1109/ULTSYM.2008.0427
