Noncavitational nonporative ultrasound elicits marked in vivo augmentation of tumor drug delivery with targeted perfluorocarbon nanoparticles

Author

Baldwin, Steven L. ; Soman, Neelesh R. ; Lanza, Gregory M. ; Wickline, Samuel A.

Author_Institution

Dept. of Internal Med. - Cardiology, Washington Univ. in St. Louis, St. Louis, MO

fYear

2008

fDate

2-5 Nov. 2008

Firstpage

566

Lastpage

569

Abstract

Background and Objective: Augmentation of local drug delivery from targeted nanoparticles (NP) with nondestructive, noncavitational clinical ultrasound (US) offers the potential to enhance therapeutic efficacy in diseases such as cancer while limiting adverse systemic side effects. This lab has demonstrated augmentation of drug delivery from alpha_vbeta₃-targeted perfluorocarbon NP and US in cancer cells in vitro (Crowder et al, 2005). The present study investigates the utility of conventional, clinical US for augmentation of drug delivery in vivo in a transgenic mouse cancer model (K14-HPV16) that develops squamous cell carcinomas.

Keywords

biomedical ultrasonics; cancer; drug delivery systems; nanobiotechnology; nanoparticles; tumours; alphavbeta3-targeted perfluorocarbon; cancer; noncavitational nonporative ultrasound; squamous cell carcinoma; systemic side effects; targeted perfluorocarbon nanoparticles; therapeutic efficacy; tumor drug delivery; Cancer; Cells (biology); Drug delivery; Ear; Fluorescence; In vivo; Mice; Nanoparticles; Neoplasms; Ultrasonic imaging; cancer; in vivo; nanoparticles; therapy; ultrasound;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 2008. IUS 2008. IEEE

Conference_Location

Beijing

Print_ISBN

978-1-4244-2428-3

Electronic_ISBN

978-1-4244-2480-1

Type

conf

DOI

10.1109/ULTSYM.2008.0136

Filename

4803564