DocumentCode :
3028914
Title :
Centrality Measures for the Human Red Blood Cell Interactome
Author :
Kurdia, Anastasia ; Daescu, Ovidiu ; Ammann, Larry ; Kakhniashvili, David ; Goodman, Steven R.
Author_Institution :
Texas Univ. Dallas, Richardson
fYear :
2007
fDate :
11-12 Nov. 2007
Firstpage :
98
Lastpage :
101
Abstract :
The red blood cell or erythrocyte is easily purified, readily available, and has a relatively simple structure. Therefore, it has become a very well studied cell in terms of protein composition and function. RBC proteomic studies performed over the last five years, by several laboratories, have identified 751 proteins within the human erythrocyte. Data describing most of their interactions are also available. This allowed us to assemble a preliminary interactome of the red blood cell. Identifying the role of certain proteins in the development of blood diseases, such as sickle cell disease, remains a challenge. To give future studies the benefit of focusing on a smaller subset of proteins, we consider several measures aimed to computationally establish the relative functional significance of protein members of the interactome.
Keywords :
blood; cellular biophysics; diseases; molecular biophysics; proteins; RBC proteomics; blood diseases; centrality measures; erythrocyte; human red blood cell interactome; protein composition; protein members; sickle cell disease; Anthropometry; Assembly; Biological cells; Biomembranes; Databases; Diseases; Humans; Proteins; Proteomics; Red blood cells;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Workshop, 2007 IEEE Dallas
Conference_Location :
Dallas, TX
Print_ISBN :
978-1-4244-1626-4
Type :
conf
DOI :
10.1109/EMBSW.2007.4454183
Filename :
4454183
Link To Document :
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