Title :
Targeted epidermal delivery of vaccines from coated micro-nanoprojection patches
Author :
Prow, Tarl W. ; Chen, Xianfeng ; Crichton, Michael ; Tiwari, Yash ; Gradassi, Francesca ; Raphelli, Kristin ; Mahony, Donna ; Fernando, Germain ; Roberts, Michael S. ; Kendall, Mark A F
Author_Institution :
Australian Inst. for Bioeng. & Nanotechnol., Queensland Univ., Brisbane, QLD
Abstract :
Transcutaneous vaccine delivery has the potential to greatly improve immunization effectiveness and safety. This work characterizes our novel micro-nanoneedles and their payload release profile in vitro and in vivo. We found that these dry-coated micro-nanoneedles quickly deliver the payload to the epidermis.
Keywords :
drug delivery systems; nanobiotechnology; needles; skin; coated micronanoprojection patches; dry-coated micronanoneedles; targeted epidermal delivery; vaccines; Australia; Drugs; Epidermis; Immune system; In vitro; In vivo; Payloads; Pharmaceutical technology; Skin; Vaccines; drug delivery; microneedle; nano-microprojection; releas; skin; transcutaneous; vaccine;
Conference_Titel :
Nanoscience and Nanotechnology, 2008. ICONN 2008. International Conference on
Conference_Location :
Melbourne, Vic.
Print_ISBN :
978-1-4244-1503-8
Electronic_ISBN :
978-1-4244-1504-5
DOI :
10.1109/ICONN.2008.4639262
