A study to investigate central feedback control in breathing pattern of weaning

Weaning the discontinuation of mechanical ventilator, it can be regarded as a stress process. It will trigger central neural feedback response to maintain the balance of our body and environments. This phenomenon is usually easily observed in breathing pattern. Weaning will cause a rhythmic change in breathing pattern. We collect data before and after weaning, weaning success and weaning failure in clinical environment. Statistical analysis methods are used to investigate this rhythm change. It also provides valuable information about respiratory system. In this paper, we showed that there is obviously difference in normalized standard deviation of after weaning data minus before weaning data between weaning success and weaning failure groups. The success groups also have lower value (bellow to zero) in after minus before weaning data than failure groups. This central feedback control phenomenon in breathing pattern may be used in good weaning index to predict weaning success and failure.