Title :
Skeletal muscle construct in vascularized cylindrical chamber
Author :
Dow, Douglas E. ; Dennis, Robert G. ; Brown, David L. ; Borschel, Gregory H.
Author_Institution :
Functional Tissue Eng. Lab., Michigan Univ., Ann Arbor, MI, USA
Abstract :
A construct containing functional skeletal muscle tissue was formed in vivo within an axially vascularized chamber seeded with myoblasts suspended in a gel. After a three week period of incubation within a rat, the construct was harvested and evaluated for force generation capability. Constructs that were seeded with myoblasts generated a positive component of force (to shorten the construct), having contractile properties similar to those of skeletal muscles.
Keywords :
biomechanics; cellular biophysics; gels; muscle; tissue engineering; contractile properties; force generation capability; gel; incubation period; myoblasts; skeletal muscle construct; skeletal muscles; vascularized cylindrical chamber; Arteries; Biomedical engineering; Diseases; Electrical stimulation; Force control; In vivo; Mechanical engineering; Muscles; Surgery; Tissue engineering;
Conference_Titel :
Biomedical Engineering, 2003. IEEE EMBS Asian-Pacific Conference on
Print_ISBN :
0-7803-7943-8
DOI :
10.1109/APBME.2003.1302608
