Co-registration Framework for Histology-registration-based Validation of Fused Multimodality Prostate Cancer Imaging

The correlation of multiple in vivo imaging modalities with graded whole-mount histology ideally requires co-registration with appropriately quantified accuracy. This work presents a framework for the co-registration of multiple in vivo prostate images with histology as a composition of pair wise registrations. This work also proposes a methodology for the measurement of the accuracy of these registrations based on a composition of target registration errors calculated from homologous landmarks in registered pairs of images. Preliminary results from the implementation of components of the framework are reported.