DocumentCode :
3041890
Title :
Dynamic Analysis of HBV Infection Model with Simulations for Anti-HBV Infection Therapy
Author :
Zheng, Yu ; Min, Lequan ; Chen, Xiao ; Ye, Yongan
Author_Institution :
Sch. of Math. & Phys., Univ. of Sci. & Technol. Beijing, Beijing, China
fYear :
2011
fDate :
14-17 Dec. 2011
Firstpage :
291
Lastpage :
295
Abstract :
Based on an amended basic virus infection model, this paper introduces a virus infection model with an immune variable. We show that if the basic infection reproductive number R of the model is less than 1, then the infection-free equilibrium of the model is globally attractive. This result implies that an infected individual with R <; 1 will eventually recover even if infected with a large amount of virus. As an application, we use this model to simulate chronical hepatitis B patients´ mean hepatitis B virus (HBV) DNA levels during 48 weeks´ anti-HBV infection treatment and 24 weeks´ treatment-free follow-up. Our numerical simulation results described the rapid reduction and relapse of patients´ mean HBV DNA levels. Further numerical simulations show that only for a treatment period of about 11 years will all infected hepatocytes be replaced by normal ones.
Keywords :
DNA; diseases; microorganisms; molecular biophysics; numerical analysis; patient treatment; DNA; HBV infection model; antiHBV infection therapy; chronical hepatitis B patients; dynamic analysis; hepatocytes; numerical simulation; time 24 week; time 48 week; virus infection model; DNA; Drugs; Educational institutions; Equations; Immune system; Mathematical model; Global stability; HBV infection; basic infection reproductive number; infection-free equilibrium; modeling anti-HBV infection therapy;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Intelligent Computation and Bio-Medical Instrumentation (ICBMI), 2011 International Conference on
Conference_Location :
Wuhan, Hubei
Print_ISBN :
978-1-4577-1152-7
Type :
conf
DOI :
10.1109/ICBMI.2011.57
Filename :
6131766
Link To Document :
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