In Vitro Detection of Neural Activity with Vertically Grown Single Platinum Nanowire

Author

Choi, D. ; Fung, A. ; Moon, H. ; Villareal, G. ; Chen, Y. ; Ho, D. ; Presser, N. ; Stupian, G. ; Leung, M.

Author_Institution

Univ. of Idaho at Moscow, Moscow, ID

fYear

2009

fDate

25-29 Jan. 2009

Firstpage

360

Lastpage

362

Abstract

We present a process for fabricating a nanoscale probing device for in vitro sensing of neural activity. Single vertical platinum (Pt) nanowires were fabricated on a microelectrode array by focused ion beam (FIB)-chemical vapor deposition (CVD) in order to improve the spatial resolution of recording and to minimize damage to the cells. Electrodes in contact with cells detected prominent spontaneous electrical activity. Such small geometry of vertical nanowires may enable probing multiple sites within a cell.

Keywords

bioelectric potentials; biomedical electrodes; biomedical measurement; cellular biophysics; chemical vapour deposition; focused ion beam technology; microelectrodes; nanofabrication; nanosensors; nanowires; neurophysiology; platinum; FIB-CVD; Pt; cell damage minimisation; chemical vapor deposition; focused ion beam; microelectrode array; nanoscale probing device fabrication; neural activity in vitro detection; rat neuroblast potential recording; spontaneous electrical activity; vertically grown single platinum nanowire; Chemical vapor deposition; Contacts; Electrodes; Geometry; In vitro; Ion beams; Microelectrodes; Nanoscale devices; Platinum; Spatial resolution;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro Electro Mechanical Systems, 2009. MEMS 2009. IEEE 22nd International Conference on

Conference_Location

Sorrento

ISSN

1084-6999

Print_ISBN

978-1-4244-2977-6

Electronic_ISBN

1084-6999

Type

conf

DOI

10.1109/MEMSYS.2009.4805393

Filename

4805393