Title :
In Vitro Detection of Neural Activity with Vertically Grown Single Platinum Nanowire
Author :
Choi, D. ; Fung, A. ; Moon, H. ; Villareal, G. ; Chen, Y. ; Ho, D. ; Presser, N. ; Stupian, G. ; Leung, M.
Author_Institution :
Univ. of Idaho at Moscow, Moscow, ID
Abstract :
We present a process for fabricating a nanoscale probing device for in vitro sensing of neural activity. Single vertical platinum (Pt) nanowires were fabricated on a microelectrode array by focused ion beam (FIB)-chemical vapor deposition (CVD) in order to improve the spatial resolution of recording and to minimize damage to the cells. Electrodes in contact with cells detected prominent spontaneous electrical activity. Such small geometry of vertical nanowires may enable probing multiple sites within a cell.
Keywords :
bioelectric potentials; biomedical electrodes; biomedical measurement; cellular biophysics; chemical vapour deposition; focused ion beam technology; microelectrodes; nanofabrication; nanosensors; nanowires; neurophysiology; platinum; FIB-CVD; Pt; cell damage minimisation; chemical vapor deposition; focused ion beam; microelectrode array; nanoscale probing device fabrication; neural activity in vitro detection; rat neuroblast potential recording; spontaneous electrical activity; vertically grown single platinum nanowire; Chemical vapor deposition; Contacts; Electrodes; Geometry; In vitro; Ion beams; Microelectrodes; Nanoscale devices; Platinum; Spatial resolution;
Conference_Titel :
Micro Electro Mechanical Systems, 2009. MEMS 2009. IEEE 22nd International Conference on
Conference_Location :
Sorrento
Print_ISBN :
978-1-4244-2977-6
Electronic_ISBN :
1084-6999
DOI :
10.1109/MEMSYS.2009.4805393
