Title :
Whole Cell Impedance Analysis of Metastatic and Non-Metastatic Cancer Cells
Author :
Kim, H.S. ; Cho, I. Y H ; Frazier, A.B. ; Chen, Z.G. ; Shin, D.M. ; Han, A.
Author_Institution :
Texas A&M Univ., College Station, TX
Abstract :
We have developed a micro electrical impedance spectroscopy (muEIS) system and utilized it for analyzing highly-metastatic and poorly-metastatic head and neck cancer (HNC) cell lines. The device is composed of 16 arrays of impedance analysis sites, with each site capable of capturing a single cell and analyzing its electrical impedance spectrum. Electrical impedance measurements on the highly-metastatic HNC cell line 686LN-M4e and the poorly-metastatic HNC cell line 686LN were conducted over a frequency range of 40 Hz to 10 MHz. The phase part of the impedance spectrums from the 686LN-M4e and 686LN cells showed clear difference. This result indicates that the muEIS system can be used to distinguish the metastatic status of HNC cell lines.
Keywords :
bioMEMS; bioelectric phenomena; cancer; cellular biophysics; electric impedance measurement; 686LN cells; 686LN-M4e cells; electrical impedance spectrum; frequency 40 Hz to 10 MHz; head and neck cancer cell lines; highly-metastatic HNC cell line; micro electrical impedance spectroscopy system; poorly-metastatic HNC cell line; whole cell impedance analysis; Cancer; Electrochemical impedance spectroscopy; Electrodes; Frequency; Impedance measurement; Medical treatment; Metastasis; Neck; Pathology; Tumors;
Conference_Titel :
Micro Electro Mechanical Systems, 2009. MEMS 2009. IEEE 22nd International Conference on
Conference_Location :
Sorrento
Print_ISBN :
978-1-4244-2977-6
Electronic_ISBN :
1084-6999
DOI :
10.1109/MEMSYS.2009.4805403
