Title :
A current-mode potentiostat for multi-target detection tested with different lactate biosensors
Author :
Ghoreishizadeh, Sara S. ; Taurino, Irene ; Carrara, Sandro ; De Micheli, G.
Author_Institution :
LSI, EPFL, Lausanne, Switzerland
Abstract :
Real-time and multi-target detection by wireless implantable devices is of increasing interest for chronic patients. In this work, electrode sharing is proposed to minimize the size of the implantable device when several three-electrode-based sensing sites are needed. An integrated potentiostat and readout circuit for a multi-target biosensor is presented. To realize this, the circuit reads out the sensor current through each working electrode in a current-mode scheme. The maximum detectable current is 8 μA and the simulated input referred current noise of the circuit is 125 pA/√Hz at 1 Hz. The circuit was fabricated in 0.18 μm technology and tested for two lactate biosensors fabricated with a commercial lactate oxidase and an engineered one. Chronoamperometry experiments performed with the circuit agree well with a commercial equipment for lactate detection up to 1 mM.
Keywords :
CMOS digital integrated circuits; biomedical electronics; biosensors; electrochemical electrodes; molecular biophysics; CMOS circuit; chronic patients; chronoamperometry; commercial lactate oxidase; current noise; current-mode potentiostat; electrochemical measurements; electrode sharing; frequency 1 Hz; integrated potentiostat; lactate biosensors; multitarget biosensor; multitarget detection; readout circuit; real-time detection; three-electrode-based sensing sites; wireless implantable devices; working electrode; Biochemistry; Biosensors; Current measurement; Electrodes; Mirrors; Noise; Chronoamperometry; Integrated circuit; Lactate; Multi-target biosensor; Potentiostat; Readout circuit;
Conference_Titel :
Biomedical Circuits and Systems Conference (BioCAS), 2012 IEEE
Conference_Location :
Hsinchu
Print_ISBN :
978-1-4673-2291-1
Electronic_ISBN :
978-1-4673-2292-8
DOI :
10.1109/BioCAS.2012.6418403
