A current-mode potentiostat for multi-target detection tested with different lactate biosensors

Author

Ghoreishizadeh, Sara S. ; Taurino, Irene ; Carrara, Sandro ; De Micheli, G.

Author_Institution

LSI, EPFL, Lausanne, Switzerland

fYear

2012

fDate

28-30 Nov. 2012

Firstpage

128

Lastpage

131

Abstract

Real-time and multi-target detection by wireless implantable devices is of increasing interest for chronic patients. In this work, electrode sharing is proposed to minimize the size of the implantable device when several three-electrode-based sensing sites are needed. An integrated potentiostat and readout circuit for a multi-target biosensor is presented. To realize this, the circuit reads out the sensor current through each working electrode in a current-mode scheme. The maximum detectable current is 8 μA and the simulated input referred current noise of the circuit is 125 pA/√Hz at 1 Hz. The circuit was fabricated in 0.18 μm technology and tested for two lactate biosensors fabricated with a commercial lactate oxidase and an engineered one. Chronoamperometry experiments performed with the circuit agree well with a commercial equipment for lactate detection up to 1 mM.

Keywords

CMOS digital integrated circuits; biomedical electronics; biosensors; electrochemical electrodes; molecular biophysics; CMOS circuit; chronic patients; chronoamperometry; commercial lactate oxidase; current noise; current-mode potentiostat; electrochemical measurements; electrode sharing; frequency 1 Hz; integrated potentiostat; lactate biosensors; multitarget biosensor; multitarget detection; readout circuit; real-time detection; three-electrode-based sensing sites; wireless implantable devices; working electrode; Biochemistry; Biosensors; Current measurement; Electrodes; Mirrors; Noise; Chronoamperometry; Integrated circuit; Lactate; Multi-target biosensor; Potentiostat; Readout circuit;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Circuits and Systems Conference (BioCAS), 2012 IEEE

Conference_Location

Hsinchu

Print_ISBN

978-1-4673-2291-1

Electronic_ISBN

978-1-4673-2292-8

Type

conf

DOI

10.1109/BioCAS.2012.6418403

Filename

6418403