Title :
Integrated optrode array for neural stimulating and recording
Author :
Sanyuan Chen ; Weihua Pei ; Qiang Gui ; Hui Zhao ; Yuanfang Chen ; Hongda Chen
Author_Institution :
State Key Lab. on Integrated Optoelectron., Inst. of Semicond., Beijing, China
Abstract :
We present the design, fabrication, simulation and characterization of a novel optrode array for light delivery and neural recording on animal optogenetic experiment in vivo. With the help of a MT connector, the optrode was arranged into 1×6 linear array and can be firmly and simply connected to optical source. The optrode was fabricated from a fiber. Fiber tip is tapered by wet etching. Au/Cr film is deposited,insulated by parylene and exposed at the tip by RIE to integrate electrical recording sites on one side of the fiber. The typical impedance at 1 KHz and output power of the optrode is 80KΩ and 13mw when evaluated in vitro. Acute animal implant experiment shows the optrode can work well in ChR2 transgenic mice.
Keywords :
bioelectric phenomena; biomedical equipment; chromium; fibre optic sensors; gold; integrated optics; metallic thin films; optical arrays; optical design techniques; optical fibre couplers; optical fibre fabrication; optical films; optical polymers; prosthetics; sputter etching; Au-Cr; Au-Cr film; ChR2 transgenic mice; MT connector; RIE; animal implantation; animal optogenetics; fiber tip; frequency 1 kHz; integrate electrical recording; integrated optrode array; light delivery; neural recording; neural stimulation; optical source; parylene; power 13 mW; wet etching; Arrays; Optical device fabrication; Optical fiber devices; Optical fibers; Optical recording; Stimulated emission;
Conference_Titel :
Biomedical Circuits and Systems Conference (BioCAS), 2012 IEEE
Conference_Location :
Hsinchu
Print_ISBN :
978-1-4673-2291-1
Electronic_ISBN :
978-1-4673-2292-8
DOI :
10.1109/BioCAS.2012.6418463
