Rapid detection of E.Coli bacteria using potassium-sensitive FETs in CMOS

Author

Nikkhoo, Nasim ; Gulak, P. Glenn ; Maxwell, Karen

Author_Institution

Dept. of Electr. & Comput. Eng., Univ. of Toronto, Toronto, ON, Canada

fYear

2012

fDate

28-30 Nov. 2012

Firstpage

168

Lastpage

171

Abstract

An integrated bacteria detection chip is implemented in 0.18μm CMOS technology. The chip has been tested using phages as biological detecting elements along with CMOS ion-selective FETs to detect the presence of a specific strain of E.coli. The chip successfully identifies the presence of living bacterial strains sensitive to the T6 phage in less than 30 minutes. Potassium-sensitive ISFETS are implemented using CMOS ISFETs and a post-processed potassium-sensitive PVC-based membrane on the top layer.

Keywords

CMOS integrated circuits; biomembranes; biosensors; cellular biophysics; ion sensitive field effect transistors; microorganisms; polymers; potassium; CMOS ISFET; CMOS ion-selective FET; CMOS technology; E.coli bacteria; E.coli strain; T6 phage; biological detecting elements; integrated bacteria detection chip; living bacterial strains; post-processed potassium-sensitive PVC-based membrane; potassium-sensitive FET; potassium-sensitive ISFET; rapid detection; size 0.18 mum; top layer; Biomembranes; CMOS integrated circuits; CMOS technology; Ions; Microorganisms; Transducers;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Circuits and Systems Conference (BioCAS), 2012 IEEE

Conference_Location

Hsinchu

Print_ISBN

978-1-4673-2291-1

Electronic_ISBN

978-1-4673-2292-8

Type

conf

DOI

10.1109/BioCAS.2012.6418470

Filename

6418470