Title :
Notice of Retraction
The Protein Network About Oscillatory Protein Expression of p53-Mdm2-p14/19ARF Feedback Loop
Author :
Liu Hui ; Han Yingrong ; Zhan Yong ; Yuan Changqing ; Liu Yuzhi ; Yu Hui ; Zhao Tongjun ; Zhuo Yizhong
Author_Institution :
Sch. of Sci., Hebei Univ. of Technol., Tianjin
Abstract :
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
We propose a dynamical model to study the dynamical mechanism of the negative feedback loop composed of p53 and Mdm2 proteins regulated by p14/19ARF. The different oscillatory behaviors for the activities of p53 and Mdm2 proteins regulated by p14/19ARF in individual of cells are described in our dynamical model. The results help us build a basal network about oscillatory behaviors between p53, Mdm2 and P14/19ARF. The dynamical model on p53-Mdm2 feedback loop regulated by p14/19ARF and its numerical results will help us understand the oscillatory behavior of p53, Mdm2 and P14/19ARF more deeply and rationally. It is also give a good model to study the relations among the network of different protein within cell.
Keywords :
biochemistry; cancer; cellular biophysics; feedback; molecular biophysics; proteins; tumours; Mdm2 proteins; negative feedback loop; oscillatory protein expression; p53-Mdm2-p14-19ARF feedback loop; protein network; Biophysics; Cancer; DNA; Feedback loop; Genetic mutations; Humans; Negative feedback loops; Neoplasms; Protein engineering; RNA;
Conference_Titel :
Bioinformatics and Biomedical Engineering, 2007. ICBBE 2007. The 1st International Conference on
Conference_Location :
Wuhan
Print_ISBN :
1-4244-1120-3
DOI :
10.1109/ICBBE.2007.14
