Hilbert Huang Transform for Predicting Apoptosis Proteins Types

Apoptosis proteins have a central role in the development and homeostasis of an organism. These proteins are very important for the understanding the mechanism of programmed cell death, and their function is related to their types. According to the classification scheme by G.P.Zhou (Zhou and Doctor,2003), the apoptosis proteins are categorized into the following four types: (1) Cytoplasmic protein; (2) Plasma membrane-bound protein; (3) Mitochondrial inner and outer proteins; (4) Other proteins. A novel method, the Hilbert-Huang transform, is applied for predicting the type of a given apoptosis protein with support vector machine. High success rates were obtained by the re-substitute test (98/98=100%), jackknife test (91/98 = 92.9%).