DocumentCode
3048083
Title
A Populations Evolution Study Using the Genotype Frequency Data of Single Nucleotide Polymorphism from Y-Chromosome
Author
Pei, Zhili ; Kong, Ying ; Shi, Xiaohu ; Lian, Zhichao ; Tang, Xuning ; Liu, Lisha ; Cao, Zhongbo ; Liang, Yanchun
Author_Institution
Key Lab. of Symbol Comput. & Knowledge Eng. of the Minist. of Educ., Jilin Univ., Changchun
fYear
2007
fDate
6-8 July 2007
Firstpage
290
Lastpage
293
Abstract
This paper proposes a novel way for the population evolution research. In the paper, it constructs the phylogenies tree of four populations using the single nucleotide polymorphism (SNP) genotype frequency of human´s Y- chromosome provided by the international Hapmap project firstly, then a mathematical model is proposed to calculate the distance of any two races for all SNP genotype frequency. The simulation results suggest that the theory of constructing phylogenetic tree by analyzing SNP genotype frequency is effective. The accuracy of the adopted processing method is also shown by the simulation results. About the origination of modern human being, the result of this study can support the ´out of Africa´ hypothesis, and this result is same as most evidences of paleontology.
Keywords
cellular biophysics; genetics; palaeontology; polymorphism; genotype frequency; genotype frequency data; human Y-chromosome; international Hapmap project; modern human being; paleontology; phylogeny tree; single nucleotide polymorphism; Africa; Analytical models; Computer science; DNA; Evolution (biology); Frequency; Genetics; Humans; Mathematical model; Phylogeny;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, 2007. ICBBE 2007. The 1st International Conference on
Conference_Location
Wuhan
Print_ISBN
1-4244-1120-3
Type
conf
DOI
10.1109/ICBBE.2007.78
Filename
4272562
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