Title :
An Algorithm Based on Fast Walsh Transform for Multiple Sequence Alignment
Author :
Huang, Beibei ; Guo, Zonglin ; Cao, Xiaojing
Author_Institution :
State Key Lab. of Software Eng., Wuhan Univ., Wuhan
Abstract :
As a NPproblem, multiple sequence alignment is solved mainly in approximative or heuristic methods, most of which are based on dynamic programming algorithm raised by Smith-Waterman in 1981. In this paper, an alignment method based on fast Walsh transform by the means of Identification of molecular subsequences is brought forward, and it adopts triplet code and subsection strategy. The method increases the differentiation through adding more vectors, it increases the precision and reduces the complexity, and Star-Alignment is introduced to make pair alignment into the alignment. Experiments show the algorithm is effective.
Keywords :
biology computing; molecular biophysics; fast Walsh transform; molecular subsequences identification; multiple sequence alignment; star-alignment; Amino acids; Dynamic programming; Educational institutions; Heuristic algorithms; Laboratories; Mathematical model; Mathematics; Software algorithms; Software engineering; Software packages;
Conference_Titel :
Bioinformatics and Biomedical Engineering, 2007. ICBBE 2007. The 1st International Conference on
Conference_Location :
Wuhan
Print_ISBN :
1-4244-1120-3
DOI :
10.1109/ICBBE.2007.99