Impedance spectroscopy studies of electroporated human breast cancer cells

The passive, electrical impedance characteristics of electroporated, MCF-7 human breast cancer is described in this paper. For this purpose, an Autolab impedance spectroscope was used. The electroporation protocol consisted of 200 V/cm, 40 ms, and 1200 V/cm, 200 ¿s pulses. The impedance characteristics of these cells displayed a negative fractal power law as expected for dielectrics. They also exhibited single dispersion Cole-Cole model. Our experiments demonstrated that the various electroporation treatment parameters result in the different curvatures of Cole-Cole model. This phenomenon proves that the effects of electroporation drug delivery to cells could be controlled in real time by monitoring impedance characteristics.