DocumentCode
3051582
Title
Collagen micro flow channel for in vitro Blood-Brain Barrier model
Author
Shibata, K. ; Terazono, H. ; Hattori, A. ; Yasuda, K.
Author_Institution
Tokyo Univ., Tokyo
fYear
2007
fDate
5-8 Nov. 2007
Firstpage
510
Lastpage
511
Abstract
We fabricated micro flow channel based on the collagen tunnel for in vitro BBB blood capillary model using collagen gel tunnel, PDMS and infrared laser. This flow channel system can add the influence of shear stress to EC and evaluate the permeability by continuous microfluidic flow during cultivation. This system is expected to become a novel tool for emulating in vivo permeability of drug candidates available only in small quantities.
Keywords
bioMEMS; biomechanics; blood; brain; cellular biophysics; laser applications in medicine; microchannel flow; molecular biophysics; permeability; proteins; blood capillary model; collagen gel tunnel; collagen microflow channel; collagen tunnel; continuous microfluidic flow; endothelial cell; in vitro Blood-Brain Barrier model; infrared laser; permeability; shear stress; Blood; Drugs; Etching; In vitro; In vivo; Laser modes; Microfluidics; Permeability; Power lasers; Stress;
fLanguage
English
Publisher
ieee
Conference_Titel
Microprocesses and Nanotechnology, 2007 Digest of papers
Conference_Location
Kyoto
Print_ISBN
978-4-9902472-4-9
Type
conf
DOI
10.1109/IMNC.2007.4456328
Filename
4456328
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