DocumentCode :
3051979
Title :
Studies on Automation of Preparation of [18F]FACBC Using a Commercial Synthesizer
Author :
Sun, Li-Quan ; Kobayashi, Masakazu ; Mori, Tetsuya ; Kawai, Kei-Ichi ; Fujibayashi, Yasuhisa
Author_Institution :
Sch. of Life Sci. & Technol., Beijing Inst. of Technol., Beijing
fYear :
2007
fDate :
6-8 July 2007
Firstpage :
1145
Lastpage :
1148
Abstract :
A simple, rapid and fully automated preparation of [18F]1-amino-3-fluorocyclobutane-l-carboxylic acid ([18F] FACBC) has been developed on a commercial [18F]FDG synthesizer, the TRACERlab MXFDG. The reaction conditions, including reaction temperature, reaction time and precursor amount, were investigated in the F-18 labeling reaction. The hydrolysis reaction of the intermediate and purification process also were discussed. The method with these appropriate parameters produced the desired PET tracer of cyclic amino acid according to an automatic procedure, including short synthesis time (45 minutes) and a suitable and reproducible radiochemical yield (25.2 plusmn 3.6 %, decay corrected). The radiochemical purity of [18F]FACBC was greater than 95%.
Keywords :
biochemistry; molecular biophysics; organic compounds; positron emission tomography; radiochemistry; F-18 labeling reaction; PET tracer; TRACERlab MXFDG; [18F] ACBC preparation; [18F]1-amino-3-fluorocyclobutane-l-carboxylic acid; cyclic amino acid; hydrolysis reaction; precursor amount; purification process; radiochemical purity; radiochemical yield; reaction temperature; reaction time; time 45 min; Amino acids; Automation; Biomedical imaging; Biomedical measurements; Neoplasms; Positron emission tomography; Synthesizers; Tumors; USA Councils; Water resources;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Bioinformatics and Biomedical Engineering, 2007. ICBBE 2007. The 1st International Conference on
Conference_Location :
Wuhan
Print_ISBN :
1-4244-1120-3
Type :
conf
DOI :
10.1109/ICBBE.2007.296
Filename :
4272780
Link To Document :
بازگشت