Title :
Photomechanical targeted drug and gene delivery to central nervous systems
Author :
Sato, Seiki ; Ando, Takehiro ; Satoh, Y. ; Nawashiro, Hiroshi ; Obara, M.
Author_Institution :
Div. of Biomed. Inf. Sci., Nat. Defense Med. Coll. Res. Inst., Tokorozawa, Japan
fDate :
June 30 2013-July 4 2013
Abstract :
We demonstrated efficient gene delivery to brain and spinal cord in rodents by applying photomechanical waves. The method was applied to recover motor function of rats with spinal cord injury. Photomechanical waves can also open the blood brain barrier.
Keywords :
blood; brain; drug delivery systems; gene therapy; injuries; neurophysiology; blood brain barrier; brain; central nervous systems; gene delivery; photomechanical targeted drug delivery; photomechanical waves; rat motor function; rodents; spinal cord injury; Drugs; Fluorescence; Laser applications; Plasmas; Proteins; Rats;
Conference_Titel :
Lasers and Electro-Optics Pacific Rim (CLEO-PR), 2013 Conference on
Conference_Location :
Kyoto
DOI :
10.1109/CLEOPR.2013.6600121
