Title :
An electrical model of the cell-electrode interface for high-density microelectrode arrays
Author :
Joye, Neil ; Schmid, Alexandre ; Leblebici, Yusuf
Author_Institution :
Microelectronic Systems Laboratroy, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland
Abstract :
A point-contact model is presented, and an area-contact model has been analytically derived in order to model the electrical characteristic of the cell-electrode interface of high-density neuron cultures. The area-contact model is presented as a model more suitable for subcellular multi-electrode resolution, which is a requisite for modeling and simulating the electrical behavior of novel high-density microelectrode arrays. Furthermore, when the electrode is aligned and centered with the cell, an optimum electrode diameter for recording the electrical activity of neural cells can be analytically derived, which is between 7–8 μm with a typical load capacitance of 10 pF.
Keywords :
Biomembranes; Capacitance; Cells (biology); Conductivity; Electric variables; Electrodes; Equivalent circuits; Microelectrodes; Neurons; Spatial resolution; Action Potentials; Animals; Computer Simulation; Computer-Aided Design; Equipment Design; Equipment Failure Analysis; Humans; Membrane Potentials; Microelectrodes; Models, Neurological; Neurons; Reproducibility of Results; Sensitivity and Specificity; Surface Properties;
Conference_Titel :
Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE
Conference_Location :
Vancouver, BC
Print_ISBN :
978-1-4244-1814-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2008.4649214
