A new approach to reconstruction of central aortic blood pressure using “adaptive” transfer function

This paper presents a new system identification approach to the reconstruction of central aortic blood pressure signal by exploiting a non-invasive peripheral blood pressure measurement. This technique, which is called the “adaptive” transfer function, is able to reconstruct the aortic blood pressure signal by characterizing the aortic-to-peripheral cardiovascular dynamics solely based on the peripheral measurement. In contrast to the previous related efforts, it does not require any a priori knowledge on the empirical and/or population-based relationship, e.g. the predetermined or generalized transfer function, as well as multiple peripheral measurements. The initial proof-of-principle on the efficacy of the adaptive transfer function is demonstrated by the experimental results from human and animal subjects.