DocumentCode :
3071312
Title :
Using an In Silico Liver to evaluate a hepatic enzyme induction mechanism
Author :
Hunt, C. Anthony ; Ropella, Glen E.P.
Author_Institution :
BioSystems Group, the Dept. of Bioengineering and Therapeutic Sciences, 513 Parnassus Ave., S-926, University of California, San Francisco, 94143, USA
fYear :
2008
fDate :
20-25 Aug. 2008
Firstpage :
2415
Lastpage :
2418
Abstract :
Will enzyme induction (EI) within different hepatic lobular zones, following initial exposure to a single xenobiotic, be homogeneous or heterogeneous? Wet-lab EI experiments, as formulated, are infeasible. The In Silico Liver (ISL) was designed in part to explore plausible answers to such questions. The ISL is synthetic, physiologically based, fine-grained, and multi-agent. It has been validated against in situ drug disposition data. Results from simulation experiments falsified the hypothesis that a uniform distribution of simulated drug passing through an ISL will produce uniform EI. The results may have a hepatic counterpart. We discuss methodological considerations regarding multi-level observation and manipulation of livers and this new class of models.
Keywords :
Anatomy; Biochemistry; Biological system modeling; Biomedical engineering; Couplings; Drugs; In vivo; Liver diseases; Testing; Visualization; Chemistry, Physical; Computer Simulation; Computers; Drug Interactions; Humans; Liver; Liver Circulation; Models, Statistical; Models, Theoretical; Monte Carlo Method; Neural Networks (Computer); Phenotype; Software; Time Factors;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE
Conference_Location :
Vancouver, BC
ISSN :
1557-170X
Print_ISBN :
978-1-4244-1814-5
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2008.4649686
Filename :
4649686
Link To Document :
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