Title :
Fixed threshold modeling of an adjustable threshold integrate-and-fire neuronal model
Author :
Seydnejad, Saeid
Author_Institution :
Ottawa Heart Institute, University of Ottawa, Canada
Abstract :
An action potential is generated when the membrane potential of a spiking neuron reaches a certain threshold. Although it is well-known that the threshold level of a neuron is not a fixed value and changes with time and neuronal parameters, its variation is often ignored in neuronal modeling due to the complexity of the analysis. Assuming a fixed threshold level, however, may produce non-realistic results. If we find a model to incorporate the impact of the variation of the threshold in a fixed threshold model we can benefit from the simplicity of the existing fixed-threshold models yet obtain more realistic results. It is shown here that, with some approximations, we can create a fixed threshold model for an integrate-and-fire neuronal model from an adjustable threshold model by some simple operations. Both models generate the same spike (action potential) pattern.
Keywords :
Biological neural networks; Biological system modeling; Biomembranes; Equations; Fires; Heart; Mathematical model; Neurons; Threshold voltage; Action Potentials; Differential Threshold; Electric Conductivity; Electric Stimulation; Humans; Membrane Potentials; Models, Biological; Models, Neurological; Models, Statistical; Neurons; Presynaptic Terminals; Reproducibility of Results; Synaptic Transmission; Time Factors;
Conference_Titel :
Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE
Conference_Location :
Vancouver, BC
Print_ISBN :
978-1-4244-1814-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2008.4649703