Title :
A Platform for Identifying MicroRNA Targeting Genes
Author :
Weng, Chia-Wei ; Chiang, ChangChih ; Huang, Chien-Hung ; Ng, Ka-Lok
Author_Institution :
Dept. of Bioinf., Asia Univ., Wufeng, Taiwan
Abstract :
We investigate the possibility that microRNA could act as an oncogene or tumor suppressor gene. Experimentally verified microRNA targeted genes information are integrated with microRNA and mRNA expression data to study this hypothesis, in which the Pearson correlation coefficient is used to quantify these relations. Cancer related microRNA and genes information are retrieved by literature search. Two microRNA targets prediction tools, miRanda and RNAHybrid, are used to obtained the binding minimum free energy and 3psilaUTR binding position for the target. A web based interface is set up for data display, which can be accessed at http://ppi.bioinfo.asia.edu.tw/mirna_target.
Keywords :
Internet; bioinformatics; cancer; data mining; genetics; macromolecules; medical computing; molecular biophysics; tumours; 3psilaUTR binding position; Pearson correlation coefficient; Web based interface; binding minimum free energy; bioinformatics; cancer related microRNA; mRNA expression profile; microRNA targeting gene identification; oncogene; tumor suppressor gene; Asia; Bioinformatics; Biomedical engineering; Cancer; Computer science; Data engineering; Humans; Neoplasms; Testing; Text mining; mRNA expression profile; microRNA; microRNA expression profile; oncogene; tumor suppressor gene;
Conference_Titel :
Bioinformatics and BioEngineering, 2009. BIBE '09. Ninth IEEE International Conference on
Conference_Location :
Taichung
Print_ISBN :
978-0-7695-3656-9
DOI :
10.1109/BIBE.2009.78
