Title :
The MAPK Signal Pathway Research and New Drug Discovery
Author :
Chen, Po-Yuan ; Jhuo, Mien-De ; Hsu, W.-T. ; Shih, Tzu-Ching ; Cheng, Tzu-Humg
Author_Institution :
Dept. of Biol. Sci. & Technol., China Med. Univ., Taichung, Taiwan
Abstract :
MAPK cell signal transduction pathways determine the survival of the cells. If one can control this pathways, and then they will prohibit the proliferation of the cancer cells. Furthermore, they will heal the cancer smoothly. In order to attain this goal, we use lots of drugs to interact with MEK1 in MAPK, by using computer aided drug design to analyze the ligand activity of proteins in MEK1.
Keywords :
bioinformatics; cancer; cellular biophysics; chemistry computing; drugs; molecular biophysics; proteins; tumours; MAPK cell signal transduction pathways; MAPK signal pathway research; MEK1 interactions; cancer cell proliferation; cancer healing process; cell survival determination; computer aided drug design; drug discovery; protein ligand activity; Bioinformatics; Biomedical engineering; Bonding; Cancer; Cells (biology); Drugs; Hospitals; Pharmaceutical technology; Proteins; Radiology; Docking; MAPK;
Conference_Titel :
Bioinformatics and BioEngineering, 2009. BIBE '09. Ninth IEEE International Conference on
Conference_Location :
Taichung
Print_ISBN :
978-0-7695-3656-9
DOI :
10.1109/BIBE.2009.80
