Electrical interactions between cardiac cells studied with “model clamp”

Author

Wilders, Ronald ; Verheijck, E. Etienne ; Kumar, Rajiv ; Golod, David ; Van Ginneken, Antoni C G ; Goolsby, William N. ; Joyner, Ronald W. ; Jongsma, Habo J.

Author_Institution

Dept. of Med. Physiol. & Sports Med., Utrecht Univ., Netherlands

Volume

1

fYear

1995

fDate

20-25 Sep 1995

Firstpage

1

Abstract

We have developed a method for coupling a single isolated cardiac cell to its mathematical model counterpart by a variable artificial intercellular conductance. With this “model clamp” technique, the model cell is coupled by any desired value of “gap junctional conductance” to an isolated cardiac cell from which electrophysiological recordings are being made in the current clamp mode. The cell model runs on a fast personal computer and communicates bidirectionally with the real cell through a data acquisition board. We have used the model clamp technique to study synchronization of rabbit sinoatrial node cells and action potential conduction between guinea pig ventricular cells

Keywords

bioelectric potentials; biological techniques; biomembrane transport; cardiology; physiological models; action potential conduction; cardiac cells; current clamp mode; data acquisition board; electrical interactions; electrophysiological recordings; fast personal computer; gap junctional conductance; guinea pig ventricular cells; mathematical model; membrane potentials; model clamp; rabbit sinoatrial node cells; real cell; single isolated cardiac cell; synchronization; variable artificial intercellular conductance; Biomembranes; Clamps; Current supplies; Data acquisition; Mathematical model; Microcomputers; Pediatrics; Physiology; Virtual manufacturing; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference

Conference_Location

Montreal, Que.

Print_ISBN

0-7803-2475-7

Type

conf

DOI

10.1109/IEMBS.1995.574970

Filename

574970