Propagation of electrical activity in the SA node

Author

Winslow, Raimond L.

Author_Institution

Dept. of Biomed. Eng., Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA

Volume

1

fYear

1995

fDate

20-25 Sep 1995

Firstpage

3

Abstract

Computational models of the sinoatrial node and atrium are used to investigate the functional role of fine strands of atrial tissue which interdigitate with and penetrate into the center of the SA node. Model results indicate that by localizing gap junction channels at the strand tips, interdigitations form a near uni-directional conduction pathway, facilitating conduction of the pacemaker potential from the SA node into the atrium, but limiting the ability of depolarizing atrial waves to perturb pacemaking behavior of central SA node cells

Keywords

biocontrol; bioelectric potentials; biomembrane transport; cardiology; physiological models; SA node; atrial tissue; atrium; central SA node cells; computational models; depolarizing atrial waves; electrical activity propagation; fine strands; functional role; gap junction channel localization; interdigitations; membrane potential; near uni-directional conduction pathway; pacemaker potential; pacemaking behavior; sinoatrial node; strand tips; Bifurcation; Biomedical computing; Biomedical engineering; Bonding; Chaos; Computational modeling; Computer simulation; Labeling; Lattices; Pacemakers;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference

Conference_Location

Montreal, Que.

Print_ISBN

0-7803-2475-7

Type

conf

DOI

10.1109/IEMBS.1995.574971

Filename

574971