A model of the adult human atrial cell

Author

Nygren, A. ; Firek, L. ; Clark, J.W. ; Lindblad, D.S. ; Clark, R.B. ; Giles, W.R.

Author_Institution

Dept. of Electr. & Comput. Eng., Rice Univ., Houston, TX, USA

Volume

1

fYear

1995

fDate

20-25 Sep 1995

Firstpage

11

Abstract

We have developed a mathematical model of the electrophysiological responses in a single cell from the adult, human atrium, based on action potential and voltage clamp data recorded at 33°C. Our formulation consists of two closely interacting parts a Hodgkin-Huxley (HH) membrane equivalent circuit model for the sarcolemma, and a fluid compartment model for the intracellular medium. These simulations produce acceptable fits to experimentally recorded action potential data, and can therefore be used to gain insight into how the ionic currents interact during the action potential in human atrial cells

Keywords

bioelectric potentials; biomembrane transport; cardiology; equivalent circuits; physiological models; 33 degC; Hodgkin-Huxley membrane equivalent circuit model; action potential; action potential data; adult human atrial cell; atrium; electrophysiological responses; fluid compartment model; intracellular medium; ionic currents; mathematical model; sarcolemma; single cell; voltage clamp data; Clamps; Equations; Equivalent circuits; Frequency dependence; Humans; Kinetic theory; Laboratories; Mathematical model; Strontium; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference

Conference_Location

Montreal, Que.

Print_ISBN

0-7803-2475-7

Type

conf

DOI

10.1109/IEMBS.1995.574975

Filename

574975