Title :
Effects of ionic concentrations on propagation speed in myocardium
Author :
Fieldman, A. ; Chernyak, Y.B. ; Cohen, R.J.
Author_Institution :
Dept. of Phys., Harvard Univ., Cambridge, MA, USA
Abstract :
The authors used their recently developed membrane model to calculate the dependence of propagation speed on shifts in the membrane´s current-voltage (I-V) relation caused by changes in the ionic environment. These shifts can be linked analytically to changes in the concentrations of cations such as Ca++ and H+. The authors calculated the propagation speed using the reaction-diffusion equation for the membrane potential and obtained a value of 55 cm/s for myocardium at standard ionic concentrations. This value varied between 12 cm/s and 85 cm/s for shifts between +46 mV and -14 mV, respectively
Keywords :
biodiffusion; bioelectric phenomena; biomembrane transport; cardiology; ions; muscle; physiological models; -14 mV; 46 mV; Ca; Ca++; H; H+; cardiac electrophysiology; cations; ionic concentrations effects; ionic environment; membrane current-voltage relation; membrane potential; myocardium propagation speed; reaction-diffusion equation; Biomembranes; Chemical technology; Eigenvalues and eigenfunctions; Kinetic theory; Myocardium; Nonlinear equations; Physics; Polarization; Steady-state; Voltage;
Conference_Titel :
Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference
Conference_Location :
Montreal, Que.
Print_ISBN :
0-7803-2475-7
DOI :
10.1109/IEMBS.1995.574980
