Title :
The role of excitation contraction coupling in cardiac muscle mechanics
Author :
Keurs, H. E D J Ter
Author_Institution :
Dept. of Med. & Med. Physiol., Calgary Univ., Alta., Canada
Abstract :
Force (F) and shortening of the myocardium during the heartbeat are determined by the amount of Ca++ bound to Troponin-C following Ca++ release by the sarcoplasmic reticulum (SR) which is triggered by the cardiac action potential. Troponin-C competes during this process both with other ligands in the cytoplasm of the cardiac myocyte and with the Ca++ extrusion from the cell as well as Ca++ re-uptake by the SR. In this discussion we address the factors that influence the main determinants of power output by the cardiac muscle
Keywords :
bioelectric potentials; biomechanics; calcium; cardiology; cellular transport; muscle; Ca; Ca++ extrusion; Ca++ re-uptake; Ca++ release; Troponin-C; cardiac action potential; cardiac muscle mechanics; cardiac myocyte; cell; cytoplasm; excitation contraction coupling; force; heartbeat; ligands; myocardium shortening; power output; sarcoplasmic reticulum; Bridges; Heart beat; Hospitals; Inhibitors; Laboratories; Muscles; Myocardium; Physiology; Steady-state; Strontium;
Conference_Titel :
Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference
Conference_Location :
Montreal, Que.
Print_ISBN :
0-7803-2475-7
DOI :
10.1109/IEMBS.1995.575011
