Title :
Macroscopic model of electroporating membrane
Author :
Krassowska, Wanda
Author_Institution :
Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA
Abstract :
This study presents a concise macroscopic model of electroporating membrane. The membrane is represented by a parallel-conductance model in which the transmembrane current consists of the capacitive current, the leakage current, and the electroporation current through a variable conductance that reflects the shock-induced creation of hydrophilic pores. This model was used to compare the responses of the electroporating and nonelectroporating membrane to strong stimuli and to examine the difference in the response of the electroporating membrane to the first and to subsequent shocks
Keywords :
bioelectric phenomena; biomembrane transport; physiological models; capacitive current; concise macroscopic model; electric shocks; electroporating membrane; hydrophilic pores; leakage current; nonelectroporating membrane; parallel-conductance model; shock-induced creation; strong stimuli; variable conductance; Biomedical engineering; Biomembranes; Capacitance; Clamps; Electric shock; Leakage current; Muscles; Predictive models; Virtual manufacturing; Voltage;
Conference_Titel :
Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference
Conference_Location :
Montreal, Que.
Print_ISBN :
0-7803-2475-7
DOI :
10.1109/IEMBS.1995.575096
