Title :
Fractal dimension and wavelet decomposition for robust microarray data clustering
Author :
Istepanian, Robert S H ; Sungoor, Ala ; Nebel, Jean-Christophe
Author_Institution :
Mobile Information and Network Technologies Research Centre (MINT), Kingston University, London, KT1 2EE UK
Abstract :
Microarrays are now established technologies which are considered as key to gene expression analysis. Their study is usually achieved by using clustering techniques. Genomic signal processing is a new area of research that combines genomics with digital signal processing methodologies. In this paper, we present a comparative analysis of two genomic signal processing methods for robust microarray data clustering. Techniques based on Fractal Dimension and Discrete Wavelet Decomposition with Vector Quantization are validated for standard data sets. Comparative analysis of the results indicates that these methods provide improved clustering accuracy compared to some conventional clustering techniques. Moreover, these classifiers don´t require any prior training procedures
Keywords :
Bioinformatics; Digital signal processing; Discrete wavelet transforms; Fractals; Gene expression; Genomics; Robustness; Signal analysis; Signal processing; Vector quantization; Algorithms; Cluster Analysis; Computers; Fractals; Genetic Vectors; Genome; Genomics; Humans; Models, Statistical; Oligonucleotide Array Sequence Analysis; Reproducibility of Results; Signal Processing, Computer-Assisted; Software;
Conference_Titel :
Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE
Conference_Location :
Vancouver, BC
Print_ISBN :
978-1-4244-1814-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2008.4650112