Title :
3D protein structure determination by THz spectroscopy and molecular modelling: case study on bovine serum albumin
Author :
Mernea, M. ; Leca, A. ; Calborean, O. ; Dinca, M.P. ; Dascalu, T. ; Mihailescu, D.
Author_Institution :
Fac. of Biol., Univ. of Bucharest, Bucharest, Romania
fDate :
Nov. 3 2009-Oct. 6 2009
Abstract :
THz spectroscopy is a very powerful tool in investigating the vibrational modes and conformational transitions of biomolecules. Here we have used THz spectroscopy to study the vibrational spectrum of bovine serum albumin, a protein whose 3D structure is yet unknown. Experimental data were fitted with theoretical spectra obtained by normal modes analysis of BSA structures generated by homology modeling.
Keywords :
molecular biophysics; proteins; submillimetre wave spectroscopy; 3D protein structure determination; bovine serum albumin; molecular modelling; terahertz spectroscopy; vibrational modes; Analytical models; Biological system modeling; Bovine; Molecular biophysics; Physics; Plasma simulation; Proteins; Root mean square; Simulated annealing; Spectroscopy;
Conference_Titel :
Terahertz and Mid Infrared Radiation: Basic Research and Practical Applications, 2009. TERA-MIR 2009. International Workshop
Conference_Location :
Turunc-Marmaris
Print_ISBN :
978-1-4244-3848-8
Electronic_ISBN :
98-1-4244-3849-5
DOI :
10.1109/TERAMIR.2009.5379635
