Implantable neural probes for chronic electrical recording and optical stimulation

Author

Fan Wu ; Stark, Ethan ; Im, Marcus ; Il-Joo Cho ; Lee Tien ; Fujun Chen ; Eui-Sung Yoon ; Buzsaki, Gyorgi ; Kaplan, David ; Berke, Joshua ; Wise, K.D. ; Euisik Yoon

Author_Institution

Dept. of Electr. Eng. & Comput. Sci., Univ. of Michigan, Ann Arbor, MI, USA

fYear

2013

fDate

9-11 Dec. 2013

Abstract

In order to advance the understanding of brain functions, it is critical to manipulate and monitor the neural circuitry in the cellular level. Supporting optogenetics, silicon probes with monolithically integrated waveguides and electrodes were designed and validated with in-vivo recording of photo-induced neural activity. For chronic applications, we developed a technology that utilizes a biodegradable silk coating to support probes with unique geometries and flexibility for reduced tissue reactions. Consistent recording has been observed for 5 weeks in rats.

Keywords

bio-optics; biodegradable materials; bioelectric phenomena; biological tissues; biomedical electrodes; biomedical electronics; biomedical materials; brain; cellular biophysics; genetic engineering; genetics; monolithic integrated circuits; neural nets; neurophysiology; patient diagnosis; prosthetics; silicon; Si; biodegradable silk coating; brain functions; cellular level; chronic application; chronic electrical recording; consistent recording; electrodes; flexibility; implantable neural probes; in-vivo recording; monolithically integrated waveguides; neural circuitry; optical stimulation; optogenetics; photo-induced neural activity; probe support; reduced tissue reactions; silicon probes; Biomedical optical imaging; Optical fibers; Optical recording; Probes; Stimulated emission;

fLanguage

English

Publisher

ieee

Conference_Titel

Electron Devices Meeting (IEDM), 2013 IEEE International

Conference_Location

Washington, DC

Type

conf

DOI

10.1109/IEDM.2013.6724589

Filename

6724589