Title :
Active CMOS biochips: an electro-addressed DNA probe
Author :
Cailat, P. ; Belleville, M. ; Clerc, F. ; Massit, C.
Author_Institution :
CEA, France
Abstract :
Many key problems in (bio)chemical sensing can be solved by reusing microelectronics and micromechanical technologies for the fabrication of microsystems converting biological or chemical response to an electrical signal. In human health monitoring and more specifically in biological analysis, new tools are emerging that are using the sequencing by hybridization technique to detect changes in the DNA-encoded chain or virus/bacteria genetic signature in patient blood. These new tools are based on multiple DNA synthetic probes (from 10 to 10/sup 4/) linked in a precise location on a substrate in the mm/sup 2/ range (biochip).
Keywords :
CMOS integrated circuits; DNA-encoded chain; active CMOS biochips; biological analysis; electro-addressed DNA probe; hybridization technique; multiple DNA synthetic probes; patient blood; virus/bacteria genetic signature; CMOS technology; Chemical technology; DNA; Fabrication; Humans; Microelectronics; Micromechanical devices; Microorganisms; Patient monitoring; Probes;
Conference_Titel :
Solid-State Circuits Conference, 1998. Digest of Technical Papers. 1998 IEEE International
Conference_Location :
San Francisco, CA, USA
Print_ISBN :
0-7803-4344-1
DOI :
10.1109/ISSCC.1998.672461
